The mechanisms of multidrug resistance of breast cancer and research progress on related reversal agents

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成果类型：

期刊论文

作者：

Yu, Shiwen;Zheng, Jinling;Zhang, Yan;Meng, Dandan;Wang, Yujue;...

通讯作者：

Zheng, Xing;Chen, HF;Li, WJ

作者机构：

[Chen, Hongfei; Meng, Dandan; Yu, Shiwen; Zheng, Xing; Wang, Yujue; Yang, Zehua; Mi, Pengbing; Zhang, Yan; Zheng, X; Zheng, Jinling] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, China Hunan Prov Key Lab Tumor Microenvironm Resp, Sch Pharmaceut Sci,Hengyang Med Sch,Hunan Prov Sc, 28 Changshengxi Rd, Hengyang 421001, Peoples R China.

[Li, Wenjun; Zhang, Xu; Meng, Dandan; Shabiti, Shayibai; Yu, Shiwen; Xu, Xiaoyu; Liang, Na; Wang, Zixi; Li, WJ; Zheng, Jinling] Chinese Acad Sci, Guangdong Key Lab Nanomed, Shenzhen Engn Lab Nanomed & Nano Formulat, SIAT, Shenzhen 518055, Peoples R China.

[Li, Wenjun; Yang, Zehua; Wang, Zixi] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

[Zheng, Xing] Hunan Vocat Coll Sci & Technol, Dept Pharm, Third Zhongyi Shan Rd, Changsha 425101, Hunan, Peoples R China.

通讯机构：

[Chen, HF ; Zheng, X] U

[Li, WJ ] C

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, China Hunan Prov Key Lab Tumor Microenvironm Resp, Sch Pharmaceut Sci,Hengyang Med Sch,Hunan Prov Sc, 28 Changshengxi Rd, Hengyang 421001, Peoples R China.

Chinese Acad Sci, Guangdong Key Lab Nanomed, Shenzhen Engn Lab Nanomed & Nano Formulat, SIAT, Shenzhen 518055, Peoples R China.

语种：

英文

关键词：

Breast cancer;Lead compounds;Multidrug resistance

期刊：

Bioorganic & Medicinal Chemistry

ISSN：

0968-0896

年：

2023

卷：

页码：

117486

DOI：

10.1016/j.bmc.2023.117486

基金类别：

Hunan Provincial Natural Science Foundation of China [2018JJ3456]; Scientific Research Fund of Hunan Provincial Education Department [17C1398]; General project of Hengyang Science and Technology Board [2016KJ62]; Hunan Province College Students Research Learning and Innovative Experiment Project [2018478]; Fund of Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [000200075]; Teaching Research and Reform Project of University of South China [2017XJGYB43]; Guangdong Natural Science Foundation of Research Team [2021A1515010195]; Shenzhen Science and Technology Program [GJHZ20200731095206020, JCYJ20210324101403009]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Chemotherapy is the mainstay in the treatment of breast cancer. However, many drugs that are commonly used in clinical practice have a high incidence of side effects and multidrug resistance (MDR), which is mainly caused by overexpression of drug transporters and related enzymes in breast cancer cells. In recent years, researchers have been working hard to find newer and safer drugs to overcome MDR in breast cancer. In this review, we provide the molecule mechanism of MDR in breast cancer, categorize potential lead compounds that inhibit single or multiple drug transporter proteins, as well as...

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The mechanisms of multidrug resistance of breast cancer and research progress on related reversal agents

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