With the development of the health service in china, the old talent-training program for clinical medicine major was failed in meeting higher demands for talents of clinical medicine. To create the new talent-training program, therefore, has become the main content of teaching reform for medical col- leges and universities. Taking University of South China as an example, the paper analyzed the changing trend of talent-training program for five-year clinical medicine majors from talent-training goal, curriculum system, practical teaching and content of courses, which proposed some thoughts on t...