PINK1/Parkin-mediated mitophagy promotes apelin-13-induced vascular smooth muscle cell proliferation by AMPK alpha and exacerbates atherosclerotic lesions

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

He, Lu;Zhou, Qionglin;Huang, Zheng;Xu, Jin;Zhou, Hong;...

通讯作者：

Luo, Xuling;Li, Lanfang;Chen, Linxi

作者机构：

[Huang, Shifang; Lv, Deguan; Luo, Xuling; Zhou, Qionglin; Tang, Mingzhu; Huang, Zheng; Luo, XL; Li, Lanfang; Chen, Linxi; Lu, Liqun; Xu, Jin; He, Lu; Zhou, Hong] Univ South China, Inst Pharm & Pharmacol, Prov Cooperat Innovat Ctr Mol Target New Drug Stu, Learning Key Lab Pharmacoprote, Hengyang, Peoples R China.

[He, Lu] Univ South China, Affiliated Hosp 1, Dept Neurosurg, Hengyang, Peoples R China.

[Zhong, Jiuchang] Capital Med Univ, Heart Ctr, Beijing Chaoyang Hosp, Beijing, Peoples R China.

[Zhong, Jiuchang] Capital Med Univ, Beijing Key Lab Hypertens, Beijing Chaoyang Hosp, Beijing, Peoples R China.

[Chen, Jian-xiong] Univ Mississippi, Med Ctr, Dept Pharmacol & Toxicol, Jackson, MS 39216 USA.

通讯机构：

[Luo, XL; Li, LF; Chen, LX] U

Univ South China, Inst Pharm & Pharmacol, Prov Cooperat Innovat Ctr Mol Target New Drug Stu, Learning Key Lab Pharmacoprote, Hengyang, Peoples R China.

语种：

英文

关键词：

AMPKα;Apelin-13;atherosclerosis (AS);mitophagy;vascular smooth muscle cell proliferation

期刊：

JOURNAL OF CELLULAR PHYSIOLOGY

ISSN：

0021-9541

年：

2019

卷：

234

期：

页码：

8668-8682

DOI：

10.1002/jcp.27527

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81470434, 81770253, 81803535]; National Basic Research Program of ChinaNational Basic Research Program of China [2014CB542300]; National Natural Science Foundation of HunanNatural Science Foundation of Hunan Province [2018JJ6070, 2018JJ6119]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Aberrant proliferation of vascular smooth muscle cells (VSMC) is a critical contributor to the pathogenesis of atherosclerosis (AS). Our previous studies have demonstrated that apelin-13/APJ confers a proliferative response in VSMC, however, its underlying mechanism remains elusive. In this study, we aimed to investigate the role of mitophagy in apelin-13-induced VSMC proliferation and atherosclerotic lesions in apolipoprotein E knockout (ApoE-/-) mice. Apelin-13 enhances human aortic VSMC proliferation and proliferative regulator proliferating...

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PINK1/Parkin-mediated mitophagy promotes apelin-13-induced vascular smooth muscle cell proliferation by AMPK alpha and exacerbates atherosclerotic lesions

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