Spermidine prevents high glucose-induced senescence in HT-22 cells by upregulation of CB1 receptor

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成果类型：

期刊论文

作者：

Zhu, Wei-Wen;Xiao, Fan;Tang, Yi-Yun;Zou, Wei*;Li, Xiang;...

通讯作者：

Zou, Wei;Tang, Xiao-Qing

作者机构：

[Wang, Ai-Ping; Xiao, Fan; Tang, Xiao-Qing; Zou, Wei; Zhu, Wei-Wen; Li, Xiang; Tang, Yi-Yun; Zhang, Ping] Univ South China, Inst Neurosci, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang, Hunan, Peoples R China.

[Xiao, Fan; Tang, Xiao-Qing; Zhu, Wei-Wen; Tang, Yi-Yun] Univ South China, Dept Physiol, Coll Med, Hengyang, Hunan, Peoples R China.

[Xiao, Fan; Zou, Wei; Zhang, Ping] Univ South China, Affiliated Nanhua Hosp, Dept Neurol, Hengyang, Hunan, Peoples R China.

[Li, Xiang] Univ South China, Affiliated Hosp 1, Dept Anesthesiol, Hengyang, Hunan, Peoples R China.

[Wang, Ai-Ping] Univ South China, Dept Anat, Coll Med, Hengyang, Hunan, Peoples R China.

通讯机构：

[Zou, Wei; Tang, Xiao-Qing] U

Univ South China, Affiliated Nanhua Hosp, Dept Neurol, Hengyang, Hunan, Peoples R China.

Univ South China, Coll Med, Inst Neurosci, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

CB1 receptor;diabetic encephalopathy;high glucose;hyperglyceamia;senescence;spermidine

期刊：

Clinical and Experimental Pharmacology and Physiology

ISSN：

0305-1870

年：

2018

卷：

期：

页码：

832-840

DOI：

10.1111/1440-1681.12955

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81671057]; Major Research Topics of the Health and Family Planning Commission of Hunan province [A2017020]; Key Projects of the Education Department of Hunan province [17A187]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Hyperglycemia‐induced neurotoxicity involves in the pathogenesis of diabetic encephalopathy and neuronal senescence is one of the worst effects of hyperglycemic neurotoxicity. Cannabinoid receptor type 1 (CB1) has neuroprotective function in a series of neuropathy. Spermidine (Spd) has anti‐aging function in many tissues. However, the role of Spd in hyperglycemia‐induced neuronal senescence remains unexplored. Therefore, we used high glucose (HG)‐treated HT‐22 cell as vitro model to investigate whether Spd protects neurons against hypergly...

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Spermidine prevents high glucose-induced senescence in HT-22 cells by upregulation of CB1 receptor

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