Chronic unpredictable mild stress promotes atherosclerosis via HMGB1/TLR4-mediated downregulation of PPARγ/LXRα/ABCA1 in ApoE-/- Mice

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成果类型：

期刊论文

作者：

Gu, Hong-Feng;Li, Na;Xu, Zhao-Qian;Hu, Lu;Li, Hui;...

通讯作者：

Tang, Ya-Ling;Liao, Duan-Fang

作者机构：

[Gu, Hong-Feng; Xu, Zhao-Qian; Chen, Ru-Meng; Tang, Ya-Ling; Li, Na; Hu, Lu; Li, Hui; Zhang, Rong-Jie; Liao, Duan-Fang; Tang, YL; Liao, DF] Univ South China, Dept Physiol, Hengyang, Peoples R China.

[Gu, Hong-Feng; Xu, Zhao-Qian; Chen, Ru-Meng; Tang, Ya-Ling; Li, Na; Hu, Lu; Li, Hui; Zhang, Rong-Jie; Liao, Duan-Fang; Tang, YL; Liao, DF] Univ South China, Inst Neurosci, Hengyang, Peoples R China.

[Zheng, Xi-Long; Liao, Duan-Fang] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha, Hunan, Peoples R China.

通讯机构：

[Tang, YL; Liao, DF] U

[Liao, Duan-Fang] H

Univ South China, Dept Physiol, Hengyang, Peoples R China.

Univ South China, Inst Neurosci, Hengyang, Peoples R China.

Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, State Key Lab Chinese Med Powder & Med Innovat Hu, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

ABCA1;HMGB1;atherosclerosis;chronic stress;inflammation;toll-like receptor 4

期刊：

Frontiers in Physiology

ISSN：

1664-042X

年：

2019

卷：

期：

MAR

页码：

165

DOI：

10.3389/fphys.2019.00165

基金类别：

This work was supported by grants from the National Natural Science Foundation of China (Grants Nos. 81500349 and 81670268), the Natural Science Foundation of Hunan Province, China (Grant No. 2016JJ2112), the Graduate Student Scientific Research Innovation Project of Hunan Province (Grant No. CX2017B548), and grants from the Health and Family Planning Commission of Hunan Province, China (Grant No. B2017048).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Background: Although our previous studies have confirmed that the activation of TLR4 is implicated in the development of atherosclerosis induced by chronic unpredicted mild stress (CUMS), the underling mechanism is largely unclear. Here, we hypothesized that CUMS accelerates atherosclerotic development through lowering PPARγ/LXRα-ABCA1 expression via HMGB1/TLR4 signaling. Methods: In present study, CUMS atherosclerotic animal models were established with AopE-/- mice, and CUMS Raw 264.7 macrophage models were mimicked by high corticosterone t...

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Chronic unpredictable mild stress promotes atherosclerosis via HMGB1/TLR4-mediated downregulation of PPARγ/LXRα/ABCA1 in ApoE-/- Mice

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