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Design and Synthesis of Fluorinated Amphiphile as 19F MRI/Fluorescence Dual-Imaging Agent by Tuning the Self-Assembly

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成果类型:
期刊论文
作者:
Bo, Shaowei;Song, Cong;Li, Yu;Yu, Weijiang;Chen, Shizhen;...
通讯作者:
Zheng, Xing
作者机构:
[Bo, Shaowei; Zheng, Xing] Univ South China, Inst Pharm Pharmacol, Hengyang 421001, Peoples R China.
[Li, Yu; Yu, Weijiang; Jiang, Zhong-Xing; Bo, Shaowei; Song, Cong; Yang, Zhigang] Wuhan Univ, Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Peoples R China.
[Li, Yu; Yu, Weijiang; Jiang, Zhong-Xing; Bo, Shaowei; Song, Cong; Yang, Zhigang] Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China.
[Zhou, Xin; Chen, Shizhen] Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, Key Lab Magnet Resonance Biol Syst,State Key Lab, Wuhan 430071, Peoples R China.
[Jiang, Zhong-Xing; Bo, Shaowei; Zheng, Xing] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.
通讯机构:
[Zheng, Xing] U
Univ South China, Inst Pharm Pharmacol, Hengyang 421001, Peoples R China.
语种:
英文
关键词:
Amphiphiles;Biocompatibility;Chemical reactions;Fluorescence imaging;Fluorophores;Image processing;Magnetic resonance imaging;Medical applications;Self assembly;Solubility;Aqueous solubility;Biomedical applications;Dual-modal imaging;Dual-modality imaging;Fluorinated amphiphiles;Imaging modality;Phenylacetylenes;Sonogashira coupling reactions;Molecular imaging;1,2,4,5 tetraiodobenzene;amphophile;fluorescent dye;fluorine;fluorine derivative;macrogol;phenylacetylene;unclassified drug;water;fluorescent dye;surfactant;animal experiment;aqueous solution;Article;biocompatibility;cell viability;controlled study;cytotoxicity;dispersion;drug design;drug solubility;drug synthesis;female;fluorescence imaging;fluorination;fluorine nuclear magnetic resonance;HeLa cell line;human;human cell;hydrogenation;in vitro study;in vivo study;mouse;nonhuman;signal processing;Sonogashira reaction;spectral sensitivity;chemistry;fluorescence;fluorescence imaging;halogenation;nuclear magnetic resonance imaging;synthesis;Fluorescence;Fluorescent Dyes;Halogenation;Magnetic Resonance Imaging;Optical Imaging;Surface-Active Agents
期刊:
JOURNAL OF ORGANIC CHEMISTRY
ISSN:
0022-3263
年:
2015
卷:
80
期:
12
页码:
6360-6366
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21372181, 81227902, 21305156, 81273537]
机构署名:
本校为第一且通讯机构
院系归属:
药学与生物科学学院
摘要:
Both 19F MRI and optical imaging are powerful noninvasive molecular imaging modalities in biomedical applications. To integrate these two complementary imaging modalities, the design and synthesis of a novel 19F MRI/fluorescence dual-modal imaging agent is reported herein. Through Sonogashira coupling reaction between the fluorinated phenylacetylene and 1,2,4,5-tetraiodobenzene, a fluorophore with 48 symmetrical fluorines at its periphery was constructed with high efficacy. High aqueous solubility was achieved by PEGylation of the fluorophore w...

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