Design and Synthesis of Fluorinated Amphiphile as 19F MRI/Fluorescence Dual-Imaging Agent by Tuning the Self-Assembly

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Bo, Shaowei;Song, Cong;Li, Yu;Yu, Weijiang;Chen, Shizhen;...

通讯作者：

Zheng, Xing

作者机构：

[Bo, Shaowei; Zheng, Xing] Univ South China, Inst Pharm Pharmacol, Hengyang 421001, Peoples R China.

[Li, Yu; Yu, Weijiang; Jiang, Zhong-Xing; Bo, Shaowei; Song, Cong; Yang, Zhigang] Wuhan Univ, Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Peoples R China.

[Li, Yu; Yu, Weijiang; Jiang, Zhong-Xing; Bo, Shaowei; Song, Cong; Yang, Zhigang] Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China.

[Zhou, Xin; Chen, Shizhen] Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, Key Lab Magnet Resonance Biol Syst,State Key Lab, Wuhan 430071, Peoples R China.

[Jiang, Zhong-Xing; Bo, Shaowei; Zheng, Xing] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

通讯机构：

[Zheng, Xing] U

Univ South China, Inst Pharm Pharmacol, Hengyang 421001, Peoples R China.

语种：

英文

期刊：

JOURNAL OF ORGANIC CHEMISTRY

ISSN：

0022-3263

年：

2015

卷：

期：

页码：

6360-6366

DOI：

10.1021/acs.joc.5b00810

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21372181, 81227902, 21305156, 81273537]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Both 19F MRI and optical imaging are powerful noninvasive molecular imaging modalities in biomedical applications. To integrate these two complementary imaging modalities, the design and synthesis of a novel 19F MRI/fluorescence dual-modal imaging agent is reported herein. Through Sonogashira coupling reaction between the fluorinated phenylacetylene and 1,2,4,5-tetraiodobenzene, a fluorophore with 48 symmetrical fluorines at its periphery was constructed with high efficacy. High aqueous solubility was achieved by PEGylation of the fluorophore w...

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Design and Synthesis of Fluorinated Amphiphile as 19F MRI/Fluorescence Dual-Imaging Agent by Tuning the Self-Assembly

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