Design and Synthesis of Fluorinated Dendrimers for Sensitive 19F MRI

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yu, Weijiang;Yang, Yuqi;Bo, Shaowei;Li, Yu;Chen, Shizhen;...

通讯作者：

Jiang, Zhong-Xing

作者机构：

[Li, Yu; Yu, Weijiang; Jiang, Zhong-Xing; Yang, Zhigang] Wuhan Univ, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ, Wuhan 430071, Peoples R China.

[Li, Yu; Yu, Weijiang; Jiang, Zhong-Xing; Yang, Zhigang] Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China.

[Yang, Yuqi; Zhou, Xin; Chen, Shizhen] Chinese Acad Sci, Wuhan Inst Phys & Math, Natl Ctr Magnet Resonance Wuhan, Key Lab Magnet Resonance Biol Syst,State Key Lab, Wuhan 430071, Peoples R China.

[Jiang, Zhong-Xing; Bo, Shaowei; Zheng, Xing] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Educ Dept, Hengyang 421001, Peoples R China.

[Bo, Shaowei; Zheng, Xing] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

通讯机构：

[Jiang, Zhong-Xing] W

Wuhan Univ, Key Lab Combinatorial Biosynth & Drug Discovery, Minist Educ, Wuhan 430071, Peoples R China.

语种：

英文

期刊：

JOURNAL OF ORGANIC CHEMISTRY

ISSN：

0022-3263

年：

2015

卷：

期：

页码：

4443-4449

DOI：

10.1021/acs.joc.5b00294

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21372181, 81227902, 21305156]

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

To achieve high sensitivity for 19F MRI, a class of novel dendritic molecules with multiple pseudosymmetrical fluorines was designed and efficiently synthesized. Through iterative bromination and Williamson ether synthesis under mild conditions, a fluorinated dendrimer with 540 pseudosymmetrical fluorines was conveniently prepared without performing the group protection in a convergent way. The dendrimer is characterized by a strong 19F NMR peak and short relaxation times. Eventually, an appreciably enhanced 19F MRI at an extremely low concentr...

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Design and Synthesis of Fluorinated Dendrimers for Sensitive 19F MRI

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