Polytropic Influence of TRIB3 rs2295490 Genetic Polymorphism on Response to Antihypertensive Agents in Patients With Essential Hypertension

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成果类型：

期刊论文

作者：

Zhou, Jiecan;He, Fazhong;Sun, Bao;Liu, Rong;Gao, Yongchao;...

通讯作者：

Zhang, Wei;Li, Jianmin;Xu, Linyong

作者机构：

[Gao, Yongchao; Ren, Huan; Zhou, Jiecan; Liu, Rong; Zhang, Wei; Chen, Xiaoping; Zhou, Honghao; Liu, Zhaoqian; He, Fazhong; Sun, Bao] Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha, Hunan, Peoples R China.

[Gao, Yongchao; Ren, Huan; Zhou, Jiecan; Liu, Rong; Zhang, Wei; Chen, Xiaoping; Zhou, Honghao; Liu, Zhaoqian; He, Fazhong; Sun, Bao] Cent S Univ, Pharmacogenet Res Inst, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha, Hunan, Peoples R China.

[Gao, Yongchao; Ren, Huan; Zhou, Jiecan; Liu, Rong; Zhang, Wei; Chen, Xiaoping; Zhou, Honghao; Liu, Zhaoqian; He, Fazhong; Sun, Bao] Cent S Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr, Changsha, Hunan, Peoples R China.

[Zhou, Jiecan] Univ South China, Affiliated Hosp 1, Pharm Dept, Hengyang, Peoples R China.

[Shu, Yan] Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA.

通讯机构：

[Zhang, Wei; Xu, Linyong] C

[Li, Jianmin] H

Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha, Hunan, Peoples R China.

Cent S Univ, Pharmacogenet Res Inst, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha, Hunan, Peoples R China.

Cent S Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

TRIB3;antihypertensive agents;essential hypertension;polymorphism;rs2295490

期刊：

Frontiers in Pharmacology

ISSN：

1663-9812

年：

2019

卷：

页码：

236

DOI：

10.3389/fphar.2019.00236

基金类别：

The work was supported by National Scientific Foundation of China (Nos. 81573511, 81874329, 81522048, and 81273595), the National Key R&D Plan (No. 2016YFC0905000), the ‘863’ Project (No. 2012AA02A518).

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本校为其他机构

摘要：

Tribbles homolog 3 (TRIB3) mediating signaling pathways are closely related to blood pressure regulation. Our previous findings suggested a greater benefit on vascular outcomes in patients carrying TRIB3 (251, A > G, rs2295490) G allele with good glucose and blood pressure control. And TRIB3 (rs2295490) AG/GG genotypes were found to reduce primary vascular events in type 2 diabetic patients who received intensive glucose treatment as compared to those receiving standard glucose treatment. However, the effect of TRIB3 genetic variation on antihypertensives was not clear in essential hypertensio...

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Polytropic Influence of TRIB3 rs2295490 Genetic Polymorphism on Response to Antihypertensive Agents in Patients With Essential Hypertension

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