Influences of repeated exposure to low levels of TiO2 nanoparticles on Kruppel-like factors in 3D Caco-2 spheroids and mouse intestines

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成果类型：

期刊论文

作者：

Cao, Wandi;Liu, Mingkang;Wang, Canyang;Jing, Guoxing;Cao, Yi

通讯作者：

Guoxing Jing<&wdkj&>Yi Cao

作者机构：

[Liu, Mingkang; Jing, Guoxing; Cao, Wandi] Xiangtan Univ, Sch Chem Engn, Xiangtan, Peoples R China.

[Wang, Canyang; Cao, Yi] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang, Peoples R China.

[Jing, Guoxing] Xiangtan Univ, Sch Chem Engn, Xiangtan 511105, Peoples R China.

[Cao, Yi] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haza, Hengyang 421001, Peoples R China.

通讯机构：

[Guoxing Jing] S

[Yi Cao] H

School of Chemical Engineering, Xiangtan University, Xiangtan, China<&wdkj&>Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, Hengyang Medical School, University of South China, Hengyang, China

语种：

英文

关键词：

3D Caco-2 spheroids;Kruppel-like factors (KLFs);mouse intestines;RNA-sequencing;TiO2 nanoparticles (NPs)

期刊：

Journal of Applied Toxicology

ISSN：

0260-437X

年：

2023

卷：

期：

页码：

706-718

DOI：

10.1002/jat.4420

基金类别：

National Natural Science Foundation of China; [31871858]

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Kruppel-like factors (KLFs) are a set of transcription factors (TFs) involved in the regulation of many basic biological processes, and recent studies suggested that nanoparticles (NPs) were capable to change KLFs in different models even at non-cytotoxic concentrations. In this study, we repeatedly exposed 3D Caco-2 spheroids and mice to TiO(2) NPs, one of the most frequently used metal oxide NPs, and investigated the changes of KLF-signaling pathways based on RNA-sequencing. Although the internalization of TiO(2) NPs did not induce cytotoxici...

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Influences of repeated exposure to low levels of TiO2 nanoparticles on Kruppel-like factors in 3D Caco-2 spheroids and mouse intestines

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