The long noncoding RNA LUCAT1 promotes colorectal cancer cell proliferation by antagonizing Nucleolin to regulate MYC expression

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Wu, Runliu;Li, Liang;Bai, Yang;Yu, Bowen;Xie, Canbin;...

通讯作者：

Li, Xiaorong;Lin, Changwei

作者机构：

[Li, Xiaorong; Yu, Bowen; Wu, Hao; Wu, Runliu; Bai, Yang; Xie, Canbin; Zhang, Yi; Lin, Changwei] Cent South Univ, XiangYa Hosp 3, Dept Gastrointestinal Surg, Changsha 410013, Hunan, Peoples R China.

[Li, Liang] Univ South China, Sch Med, Five Year Program Clin Med, Hengyang 421001, Hunan, Peoples R China.

[Huang, Lihua] Cent South Univ, XiangYa Hosp 3, Ctr Expt Med, Changsha 410013, Hunan, Peoples R China.

[Yan, Yichao] Peking Univ Int Hosp, Dept Gastroenterol Surg, Beijing 102206, Peoples R China.

[Lin, Changwei] Cent South Univ, Sch Life Sci, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Xiaorong Li; Changwei Lin] D

Department of Gastrointestinal surgery, The Third XiangYa Hospital of Central South University, Changsha, Hunan, 410013, China.

School of Life Sciences, Central South University, Changsha, Hunan, 410078, China.

语种：

英文

期刊：

CELL DEATH & DISEASE

ISSN：

2041-4889

年：

2020

卷：

期：

页码：

908

DOI：

10.1038/s41419-020-03095-4

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81602568, 81773130, 81702336]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M643009]; National Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ50906]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

The long noncoding RNA (lncRNA) LUCAT1 was recently reported to be upregulated and to play an essential role in multiple cancer types, especially colorectal cancer (CRC), but the molecular mechanisms of LUCAT1 in CRC are mostly unreported. Here, a systematic analysis of LUACT1 expression is performed with data from TCGA database and clinic CRC samples. LUCAT1 is identified as a putative oncogene, which is significantly upregulated in CRC and is associated with poor prognosis. Loss of LUCAT1 restricts CRC proliferative capacities in vitro and in vivo. Mechanically, NCL is identified as the prot...

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The long noncoding RNA LUCAT1 promotes colorectal cancer cell proliferation by antagonizing Nucleolin to regulate MYC expression

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