De Novo Design of Near‐Infrared Fluorescent Agents Activated by Peroxynitrite and Glutathione‐Responsive Imaging for Diabetic Liver Disease

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成果类型：

期刊论文

作者：

Jiang, Renfeng;Zhang, Hongshuai;Liu, Qian;Yang, Xuefeng;He, Longwei*;...

通讯作者：

He, Longwei;Cheng, D

作者机构：

[Cheng, Dan; He, Longwei; He, LW; Jiang, Renfeng] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China.

[Cheng, Dan; Liu, Qian; Zhang, Hongshuai; Yang, Xuefeng] Univ South China, Affiliated Nanhua Hosp, Hunan Prov Clin Res Ctr Metab Associated Fatty Liv, Clin Res Inst,Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China.

[Cheng, Dan; Yuan, Lin] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China.

通讯机构：

[Cheng, D ; He, LW] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dru, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China.

Univ South China, Affiliated Nanhua Hosp, Hunan Prov Clin Res Ctr Metab Associated Fatty Liv, Clin Res Inst,Hengyang Med Sch, Hengyang 421002, Hunan, Peoples R China.

Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemo Biosensing & Chemometr, Changsha 410082, Peoples R China.

语种：

英文

关键词：

diabetic liver disease;high sensitivity;NIR fluorescent agents;peroxynitrite and glutathione;redox imbalance

期刊：

Advanced Healthcare Materials

ISSN：

2192-2640

年：

2024

卷：

期：

页码：

2302466-

DOI：

10.1002/adhm.202302466

基金类别：

R.J. and H.Z. contributed equally to this work. This work was supported by the Science and Technology Project of Hunan Province (2021RC3108), the Hunan Provincial Natural Science Foundation of China (2022JJ10042, 2022JJ30484), the Special Funding for the C [2021RC3108]; Science and Technology Project of Hunan Province [2022JJ10042, 2022JJ30484]; Hunan Provincial Natural Science Foundation of China [2021SK4031]; Special Funding for the Construction of Innovative Provinces in Hunan [2020T130184]; China Postdoctoral Science Foundation

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Two activatable NIR fluorescent agents NTCF‐ONOO− and NTCF‐GSH are de novo designed and synthesized, which can response peroxynitrite and glutathione with high sensitivity, good stability, and high selectivity in vitro. They are applied to preliminarily explore the possible redox imbalance mechanism of diabetes and to further evaluate the oxidative stress state in the complex diabetes liver disease process in vivo. Abstract Diabetes and its complications, such as diabetes liver disease, is a major problem puzzling people's health. The detect...

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De Novo Design of Near‐Infrared Fluorescent Agents Activated by Peroxynitrite and Glutathione‐Responsive Imaging for Diabetic Liver Disease

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