Genetic characterization conferred co-resistance to isoniazid and ethionamide in mycobacterium tuberculosis isolates from Southern Xinjiang, China

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Cao, Bin;Mijiti, Xiaokaiti;Deng, Le-Le;Wang, Quan;Yu, Jin-Jie;...

通讯作者：

Yuan, XQ;Li, GL

作者机构：

[Yu, Jin-Jie; Yuan, Xiuqin; Yuan, XQ; Cao, Bin] Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.

[Yu, Jin-Jie; Zhao, Xiuqin; Zhao, Li-Li; Liu, Haican; Li, Guilian; Jiang, Yi; Qian, Chengyu; Cao, Bin; Fang, Dan-Ang; Deng, Le-Le; Li, Machao; Wan, Kanglin] Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Collaborat Innovat Ctr Diag & Treatment Infect Dis, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China.

[Mijiti, Xiaokaiti; Wang, Quan] Xinjiang Med Univ, Affiliated Hosp 8, Urumqi 830000, Peoples R China.

[Deng, Le-Le] Chinese Ctr Dis Control & Prevent, Natl Inst Viral Dis Control & Prevent, Beijing, Peoples R China.

[Anwaierjiang, Aiketaguli] Coll Xinjiang Uyghur Med, Hetian 848000, Peoples R China.

通讯机构：

[Li, GL ] C

[Yuan, XQ ] U

Univ South China, Sch Publ Hlth, Hengyang 421001, Peoples R China.

Chinese Ctr Dis Control & Prevent, Natl Inst Communicable Dis Control & Prevent, Collaborat Innovat Ctr Diag & Treatment Infect Dis, State Key Lab Infect Dis Prevent & Control, Beijing 102206, Peoples R China.

语种：

英文

关键词：

Mycobacterium tuberculosis;cross-resistance;ethionamide;isoniazid;mutation

期刊：

INFECTION AND DRUG RESISTANCE

ISSN：

1178-6973

年：

2023

卷：

页码：

3117-3135

DOI：

10.2147/IDR.S407525

基金类别：

This study was supported by the project (2017A03006) of the Major science and technology programs of Xinjiang Uygur Autonomous Region from department of Science and Technology, Xinjiang Uygur Autonomous Region and Mega Project of Research on the Prevention and Control of HIV/AIDS, Viral Hepatitis Infectious Diseases (2018ZX10103001-003-012) from the Ministry of Science and Technology, China. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

机构署名：

本校为第一且通讯机构

院系归属：

公共卫生学院

摘要：

BACKGROUND: Ethionamide (ETH), a structural analogue of isoniazid (INH), is used for treating multidrug-resistant tuberculosis (MDR-TB). Due to the common target InhA, INH and ETH showed cross-resistance in M. tuberculosis. This study aimed to explore the INH and ETH resistant profiles and genetic mutations conferring independent INH- or ETH-resistance and INH-ETH cross-resistance in M. tuberculosis circulating in south of Xinjiang, China. METHODS: From Sep 2017 to Dec 2018, 312 isolates were included using drug susceptibility testing (DST), spoligotyping, and whole genome sequencing (WGS) to ...

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Genetic characterization conferred co-resistance to isoniazid and ethionamide in mycobacterium tuberculosis isolates from Southern Xinjiang, China

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