Integrated metabolomic-lipidomic profiling reveals novel biomarkers and therapeutic targets for alcohol use disorder with cognitive impairment

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Shi, Li;Chen, Xiaofang;Zhou, Bojie;Yang, Shanghao;Ou, Qinglin;...

通讯作者：

Zhou, XH

作者机构：

[Yang, Shanghao; Zhou, Bojie; Ou, Qinglin; Zhou, Xuhui; Shi, Li] Hunan Univ Chinese Med, Coll Integrat Chinese & Western Med, Changsha, Peoples R China.

[Yang, Shanghao; Zhou, Bojie; Ou, Qinglin; Zhou, Xuhui; Shi, Li] Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Hunan Inst Mental Hlth, Dept Addict Med, Changsha, Peoples R China.

[Shi, Li] Univ South China, Affiliated Changsha Cent Hosp, Dept Ctr TB Diag & Treatment, Hengyang Med Sch, Changsha, Peoples R China.

[Chen, Xiaofang] Jiangxi Prov Peoples Hosp, Key Lab Digital Orthopaed, Nancang, Peoples R China.

通讯机构：

[Zhou, XH ] H

Hunan Univ Chinese Med, Coll Integrat Chinese & Western Med, Changsha, Peoples R China.

Brain Hosp Hunan Prov, Peoples Hosp Hunan Prov 2, Hunan Inst Mental Hlth, Dept Addict Med, Changsha, Peoples R China.

语种：

英文

关键词：

alcohol use disorder;cognitive impairment;Metabolomics;lipidomics;Sphingolipid metabolism;mTORC1 pathway

期刊：

FRONTIERS IN PSYCHIATRY

ISSN：

1664-0640

年：

2025

卷：

页码：

1594313

DOI：

10.3389/fpsyt.2025.1594313

基金类别：

Clinical Research Center For Addiction Disorder in Hunan Province, China; Scientific Research Project of the Hunan Health Commission, China; Foundation of Hunan Provincial Administration of Traditional Chinese Medicine, China; Hunan Provincial Health High-Level Talent Scientific Research Project, China; Hunan Province clinical medical technology innovation guide project, China [2021SK508048]; Hunan Province clinical key specialty (Addiction medicine), China; Key Clinical Specialty Construction Project of the Hunan Health Commission, China (Improvement of Diagnosis and Treatment Ability of Severe Psychiatric Diseases in Hunan Province)

机构署名：

本校为其他机构

摘要：

Purpose: Alcohol use disorder (AUD) is a chronic relapsing condition frequently complicated by cognitive impairment (CI), yet its underlying metabolic mechanisms remain poorly understood. This study aimed to identify plasma metabolic signatures and dysregulated pathways associated with AUD-CI using an integrated multi-omics approach. Methods: A prospective cohort study of 210 male participants (70 AUD-CI, 70 AUD without CI [AUD-NonCI], and 70 healthy controls [HCs]) was conducted. Plasma samples underwent LC-MS/MS-based metabolomic and lipidomic profiling. Cognitive function was assessed using...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Integrated metabolomic-lipidomic profiling reveals novel biomarkers and therapeutic targets for alcohol use disorder with cognitive impairment

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问