Photoredox-Catalyzed Three-Component Sulfonaminoalkynylation of Alkenes via a Radial/Polar Crossover

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期刊论文

作者：

Shen, Lixian;Liu, Jie;Peng, Xue;Lei, Zhengwen*;Wang, Zhen*;...

通讯作者：

Lei, Zhengwen;Wang, Zhen;Zeng, YF;Wang, Z

作者机构：

[Shen, Lixian] Univ South China, Affiliated Hosp 2, Hengyang Med Sch, Dept Pharm,Hunan Prov Key Lab Basic & Clin Pharmac, Hengyang 421001, Hunan, Peoples R China.

[Shen, Lixian; Liu, Jie; Wang, Zhen; Peng, Xue; Lei, Zhengwen; Zeng, Yao-Fu; Lei, ZW] Univ South China, Affiliated Hosp 1, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

[Wang, Zhen] Univ South China, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.

[Wang, Zhen] Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China.

通讯机构：

[Wang, Z; Zeng, YF ; Wang, Z ; Lei, ZW] U

Univ South China, Affiliated Hosp 1, Sch Pharmaceut Sci, Hengyang Med Sch, Hengyang 421001, Hunan, Peoples R China.

Univ South China, MOE Key Lab Rare Pediat Dis, Hengyang 421001, Hunan, Peoples R China.

Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China.

语种：

英文

期刊：

JOURNAL OF ORGANIC CHEMISTRY

ISSN：

0022-3263

年：

2025

卷：

期：

页码：

1656-1662

DOI：

10.1021/acs.joc.4c02796

基金类别：

National Natural Science Foundation of China [22101126]; National Natural Science Foundation of China [2024JJ5323]; Natural Science Foundation of Hunan Province [2023TP1014]; Foundation of Hunan Provincial Key Laboratory

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

We report a photoredox-catalyzed three-component sulfonaminoalkynylation of alkenes with N -aminopyridine salts and potassium alkynyltrifluoroborate salts. This aminoalkylation reaction underwent a radial/polar crossover mechanism, which was distinguished from the previous reports. A variety of β-alkynylated sulfonamides were obtained in moderate to excellent yields. The versatility of this method was further evidenced by its successful application in modifying biological molecules in advanced stages of development. We report a photoredox-cata...

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Photoredox-Catalyzed Three-Component Sulfonaminoalkynylation of Alkenes via a Radial/Polar Crossover

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