Impact of NDUFAF6 on breast cancer prognosis: linking mitochondrial regulation to immune response and PD-L1 expression

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Jiang, Baohong;Wu, Sixuan;Zeng, Lijun;Tang, Yuanbin;Luo, Lunqi;...

通讯作者：

Tan, Yeru;Li, YH

作者机构：

[Jiang, Baohong] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Pharm, Hengyang, Hunan, Peoples R China.

[Zeng, Lijun; Tan, Yeru; Li, YH; Li, Yuehua; Tang, Yuanbin; Luo, Lunqi; Ouyang, Lianjie; Feng, Wenjie; Tan, YR; Wu, Sixuan] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Oncol, Hengyang, Hunan, Peoples R China.

[Wu, Sixuan] Fujian Med Univ, Fujian Canc Hosp, Clin Oncol Sch, Fuzhou, Fujian, Peoples R China.

通讯机构：

[Li, YH ; Tan, YR] U

Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Oncol, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

Breast cancer;NDUFAF6;NRF2;PD-L1;Immune infiltration;Prognosis

期刊：

Cancer Cell International

ISSN：

1475-2867

年：

2024

卷：

期：

页码：

1-21

DOI：

10.1186/s12935-024-03244-1

基金类别：

This research was funded by the Scientific Research Fund Project of Hunan Provincial Health Commission (D202303109191, B202303109577 and D202303109450), the Natural Science Foundation of Hunan Province (2023JJ60495, 2023JJ60496) and Clinical Medical Research 4310 Program of the University of South China (20224310NHYCG07).

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Breast cancer is a major global health concern, and there is a continuous search for novel biomarkers to predict its prognosis. The mitochondrial protein NDUFAF6, previously studied in liver cancer, is now being investigated for its role in breast cancer. This study aims to explore the expression and functional significance of NDUFAF6 in breast cancer using various databases and experimental models. We analyzed breast cancer samples from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and Human Protein Atlas (HPA) databases, supp...

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Impact of NDUFAF6 on breast cancer prognosis: linking mitochondrial regulation to immune response and PD-L1 expression

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