National Natural Science Foundation of China [22074037, 22090053, 22090054, 2199108]
机构署名：
本校为其他机构
院系归属：
医学院
摘要：
Exosomes secreted from cells carry rich information from their parent cells, representing a promising biomarker for investigation of diseases. We develop a dual-nanopore biosensor using DNA aptamers to specifically recognize CD63 protein on the exosome's surface, which enables label-free exosome detection based on ionic current change. The sensor allows for sensitive detection of exosomes with a detection limit of 3.4 × 10(6) particles/mL. The dual-nanopore biosensor was able to form an intrapipette electric circuit for ionic current measureme...
