期刊论文

Lei, X.-Y.

中文

世界华人消化杂志

1009-3079

2019

27

11

715-720

10.11569/wcjd.v27.i11.715

国家自然科学基金资助项目,No.81373465 湖南省自然科学省市联合基金,No.2016JJ5010 湖南省卫生计生委科研课题,No.A2017015.

本校为第一且通讯机构

药物性肝损害(drug induced liver injury, DILI)是临床常见的一种药物不良反应,严重会引起急性肝衰竭甚至危及生命.目前常用且明确可以引起DILI的药物已经超过1000种,已经成为当今一项重点关注的世界医疗安全问题.本文对DILI发病因素、发病机制,诊断和治疗方法进行了综述,为改善DILI的预防和预后提供参考.

Drug induced liver injury (DILI) is a common adverse effect in clinical practice, which can cause acute liver failure and even threaten the life. Currently, there are over 1000 commonly used drugs that are clearly capable of causing DILI, which has become a world medical safety issue of great concern. This article reviews the etiology, pathogenesis, diagnosis, and treatment of DILI, with an aim to provide a reference for prevention and prognosis and further research of this disease. © The Author(s) 2019. Publis...