期刊论文

Yan, D.-Z.

中文

世界华人消化杂志

1009-3079

2005

13

7

864-866

10.3969/j.issn.1009-3079.2005.07.011

本校为第一且通讯机构

目的:观察水蓑衣提取物的抗肝癌细胞增生活性,为水蓑衣提取物用于肝癌治疗提供实验依据.方法:BALB/CA雌性裸鼠24只,背侧皮下接种SMMC-7721人肝癌细胞建立荷瘤裸鼠模型,14 d后随机分为对照组,低剂量水蓑衣组,高剂量水蓑衣组和羟基喜树碱组;给药20 d后检测各组移植瘤的体积和质量;并观察移植瘤的组织学变化和血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、乳酸脱氢酶(LDH)活性和肌酐(CRE)水平.结果:与对照组相比,水蓑衣组裸鼠移植瘤的体积明显减小(P＜0.05),质量显著减轻(P＜0.05);低、高剂量水蓑衣组的抑瘤率分别为46%和62%(P＜0.05).水蓑衣组裸鼠瘤组织病理改变与羟基喜树碱组相似;体质量和血清...

AIM: To assess the anti-proliferative effect of the extraction from Hygrophila salicifolia on hepatocellular carcinoma (HCC) cells, and to provide the experimental evidence for the use of Hygrophila salicifolia extraction in the therapy of hepatocarcinoma. METHODS: Twenty-four female nude mice were subcu-taneously injected with human HCC cells. After 14 days, the mice were divided equally into control group, low dose Hygrophila salicifolia group, high dose Hygrophila salicifolia group and hydroxycamptothecin group. The volume and weight of tumor were measured 20 days after treatment. Histologi...