RNA N6-methyladenosine modification-based biomarkers for absorbed ionizing radiation dose estimation

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成果类型：

期刊论文

作者：

Chen, Hongxia;Zhao, Xi;Yang, Wei;Zhang, Qi;Hao, Rongjiao;...

通讯作者：

Lu, Yiming;Zhou, GQ

作者机构：

[Zhang, Qi; Lu, Yiming; Lu, Hao; Zhao, Xi; Hao, Rongjiao; Han, Huihui; Li, Yuanfeng; Zhou, Gangqiao; Jiang, Siao; Xing, Shuang; Quan, Cheng; Chen, Hongxia; Yu, Zuyin] Beijing Inst Radiat Med, Beijing Proteome Res Ctr, Natl Ctr Prot Sci Beijing, State Key Lab Prote, Beijing, Beijing, Peoples R China.

[Wang, Qianqian; Yang, Wei] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Radiat Oncol, Beijing, Peoples R China.

[Zhang, Qi; Zhou, Gangqiao] Univ South China, Sch Med, Hengyang, Hunan, Peoples R China.

[Lu, Yiming; Hao, Rongjiao; Zhou, Gangqiao; Jiang, Siao] Univ Hebei, Sch Life Sci, Baoding, Hebei, Peoples R China.

[Feng, Changjiang] Chinese Peoples Liberat Army Gen Hosp, Med Ctr 1, Dept Thorac Surg, Beijing, Peoples R China.

通讯机构：

[Zhou, GQ ; Lu, YM] B

Beijing Inst Radiat Med, Beijing Proteome Res Ctr, Natl Ctr Prot Sci Beijing, State Key Lab Prote, Beijing, Beijing, Peoples R China.

Univ South China, Sch Med, Hengyang, Hunan, Peoples R China.

Univ Hebei, Sch Life Sci, Baoding, Hebei, Peoples R China.

Nanjing Med Univ, Sch Publ Hlth, Collaborat Innovat Ctr Personalized Canc Med, Ctr Global Hlth, Nanjing, Jiangsu, Peoples R China.

语种：

英文

期刊：

Nature Communications

ISSN：

2041-1723

年：

2023

卷：

期：

页码：

6912

DOI：

10.1038/s41467-023-42665-w

基金类别：

Natural Science Foundation of Beijing [5202025]; Natural Science Foundation of China [32270714, 32200511]; Beijing Institute of Radiation Medicine [BWS21J022, AWS21J003, AMMS-QNZD-2022-002]

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Radiation triage and biological dosimetry are critical for the medical management of massive potentially exposed individuals following radiological accidents. Here, we performed a genome-wide screening of radiation-responding mRNAs, whose N6-methyladenosine (m(6)A) levels showed significant alteration after acute irradiation. The m(6)A levels of three genes, Ncoa4, Ate1 and Fgf22, in peripheral blood mononuclear cells (PBMCs) of mice showed excellent dose-response relationships and could serve as biomarkers of radiation exposure. Especially, the RNA m(6)A of Ncoa4 maintained a high level as lo...

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RNA N6-methyladenosine modification-based biomarkers for absorbed ionizing radiation dose estimation

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