NEAT1 promotes the malignant development of bladder cancer by regulating the miR-101/VEGF-C pathway in vitro and in vivo

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Huihui;Yu, Shuang;Fei, Kuilin;Huang, Zhongxin;Deng, Shidong;...

通讯作者：

Hanfeng Xu

作者机构：

[Zhang, Huihui; Xu, Hanfeng; Deng, Shidong; Huang, Zhongxin] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Urol, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Huihui] Univ South China, Inst Hosp Adm, Hengyang 421001, Hunan, Peoples R China.

[Yu, Shuang] Peoples Hosp Liuyang, Dept Urol, Changsha 410399, Hunan, Peoples R China.

[Fei, Kuilin] Cent South Univ, Xiangya Hosp, Dept Obstet, Changsha 410008, Hunan, Peoples R China.

通讯机构：

[Hanfeng Xu] D

Department of Urology, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, People’s Republic of China

语种：

英文

关键词：

NEAT1;miR-101;VEGF-C;Bladder cancer

期刊：

BMC Urology

ISSN：

1471-2490

年：

2022

卷：

期：

页码：

1-12

DOI：

10.1186/s12894-022-01151-z

基金类别：

This study was supported by the National Natural Science Foundation of China (No. 81602241), Natural Science Foundation of Hunan Province (Nos. 2020JJ5510, 2020JJ5890), and the Research and Reform Project of Hospital Administration of University of South China (No. 2021YYGL10).

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本校为第一机构

摘要：

NEAT1 has been shown to play an oncogenic role in many kinds of cancers. However, detailed roles of NEAT1 in bladder cancer are largely unknown. In the present study, the expression of NEAT1, miR-101 and VEGF-C was detected in human bladder cancer samples. The relationship between NEAT1 and the prognosis of patients with bladder cancer was analysed. In vitro experiments explored the effects of NEAT1 on biological behaviours of bladder cancer T24 and 5637 cells. Bioinformatics prediction and luciferase assays were used to assay the regulatory mechanism of action of NEAT1 and miR-101. Loss and g...

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NEAT1 promotes the malignant development of bladder cancer by regulating the miR-101/VEGF-C pathway in vitro and in vivo

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