期刊论文

中文

中华内分泌代谢杂志

1000-6699

2004

20

6

551-555

10.3760/j.issn:1000-6699.2004.06.023

国家自然科学基金 (30 370 675)； 日本大塚制药厂新药研究基金 (2 0 0 1 8 2 8)；

本校为第一机构

目的用高脂高糖饲养的贵州小香猪观察脂蛋白脂酶活化剂NO-1886调节糖、脂代谢的作用.方法采用高脂高蔗糖饲料喂养贵州小香猪,并用NO-1886进行治疗,观察其体重、血糖、胰岛素、血浆肿瘤坏死因子α(TNF-α)、游离脂肪酸(FFA)、脂肪细胞形态的变化.结果与正常对照组相比,高脂高蔗糖喂养使小香猪脂肪细胞体积变大,血浆TNF-α和FFA以及空腹血糖水平均增高(P＜0.05～P＜0.01),而且引起胰岛素抵抗.在高脂高蔗糖饲料中添加了1%NO-1886后,与高脂高蔗糖组相比,脂肪细胞增大被抑制,血浆TNF-α、FFA和空腹血糖的浓度均显著降低(均P＜0.05),血浆葡萄糖清除率以及胰岛素分泌急性相都有了明显改善.结论NO-1886可...

Objective To investigate the effects of lipoprotein lipase activator NO-1886 on glucose and lipid metabolism in Guizhou minipigs fed with high fat/high sucrose diet. Methods Minipigs fed with high fat/high sucrose diet (HFSD) were treated with NO-1866, and their body weight, morphology of adipocytes and the levels of fasting blood glucose, insulin, tumor necrosis factor-α (TNF-α) and free fatty acids (FFA) were observed. Results As compared with control group, HFSD resulted in increment of adipocyte size and raised the plasma levels of TNF-α...