期刊论文

Yang, F

英文

TOXINS

2072-6651

2024

16

9

401-

10.3390/toxins16090401

Conceptualization, F.Y., Q.T., H.C. and J.W. (Jia Wei); methodology, H.C. and J.W. (Jiangping Wang); software, Q.T.; validation, H.C., S.Y. and X.S.; formal analysis, S.Y.; investigation, H.C.; resources, H.C.; data curation, J.W. (Jia Wei); writing—original draft preparation, Q.T. and J.W. (Jia Wei); writing—review and editing, Q.T., J.W. (Jia Wei) and F.Y.; visualization, Q.T. and J.W. (Jia Wei); supervision, F.Y.; project administration, F.Y.; funding acquisition, X.S., L.Z. and F.Y. All authors have read and agreed to the published version of the manuscript. This research was funded by the Hunan Province Key Research and Development Projects (2022SK2089); the Natural Science Foundation of Hunan Province (2024JJ6393).

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Microcystin-LR (MC-LR), frequently generated by cyanobacteria, has been demonstrated to raise the likelihood of liver disease. Few previous studies have explored the potential antagonist against MC-LR. Astaxanthin (ASX) has been shown to possess various beneficial effects in regulating lipid metabolism in the liver. However, whether ASX could alleviate MC-LR-induced hepatic lipid metabolic dysregulation is as yet unclear. In this work, the important roles and mechanisms of ASX in countering MC-LR-induced liver damage and lipid metabolic dysregulation were explored for the first time. The findi...