期刊论文

Research progress of mitochondrial DNA and cGAS-STING pathway in antibacterial and antiviral immunity

中文

中南医学科学杂志

2095-1116

2024

52

2

300-304

10.15972/j.cnki.43-1509/r.2024.02.037

国家自然科学基金(31872643)。

本校为第一机构

线粒体除了产生ATP为真核生物提供能量外,还参与抗细菌病毒感染过程。线粒体DNA(mtDNA)在各种细菌病毒感染的刺激下均能引起损伤。细菌病毒感染能够引起线粒体转录因子A蛋白丢失,或通过Ⅶ型分泌系统、线粒体抗病毒信号蛋白...展开更多 线粒体除了产生ATP为真核生物提供能量外,还参与抗细菌病毒感染过程。线粒体DNA(mtDNA)在各种细菌病毒感染的刺激下均能引起损伤。细菌病毒感染能够引起线粒体转录因子A蛋白丢失,或通过Ⅶ型分泌系统、线粒体抗病毒信号蛋白和线粒体膜通透性转换孔介导等不同方式将mtDNA释放到细胞质中从而激活环状GMP-AMP合成酶(cGAS)、DEAD盒解旋酶41、NOD样受体热蛋白结构域相关...

Mitochondria contribute to the process of resistance against bacterial and viral infections in addition to generating ATP to provide energy to eukaryotes.Damage to mitochondrial DNA(mtDNA)can occur when specific stimuli associated with bacterial or viral infections are ...MORE Mitochondria contribute to the process of resistance against bacterial and viral infections in addition to generating ATP to provide energy to eukaryotes.Damage to mitochondrial DNA(mtDNA)can occur when specific stimuli associated with bacterial or viral infections are pr...