期刊论文

Riluzole improves motor function and muscle fibrosis in amyotrophic lateral sclerosis mice

中文

中南医学科学杂志

2095-1116

2024

52

4

523-528

10.15972/j.cnki.43-1509/r.2024.04.005

82171583:国家自然科学基金 SZSM202211010:深圳市医疗卫生三名工程项目 SZXK069:深圳市医学重点学科建设经费资助项目

本校为第一机构

目的探究利鲁唑对肌萎缩侧索硬化(ALS)小鼠的运动功能和肌肉纤维化的影响。方法选取13周龄雄性转基因ALS小鼠12只,随机均分为模型组、利鲁唑组,另选取6只野生型雄性小鼠作为正常组。通过悬挂测试、爬杆测试、转棒测试、抓握...展开更多 目的探究利鲁唑对肌萎缩侧索硬化(ALS)小鼠的运动功能和肌肉纤维化的影响。方法选取13周龄雄性转基因ALS小鼠12只,随机均分为模型组、利鲁唑组,另选取6只野生型雄性小鼠作为正常组。通过悬挂测试、爬杆测试、转棒测试、抓握力测试、步态测试评估各组小鼠运动能力。比较各组小鼠体质量和血清肌酸激酶、乳酸脱氢酶水平。采用肌肉病理组织学评估肌肉萎缩情况。采用...

Aim To explore the effects of Riluzole on motor function and muscle fibrosis in mice with amyotrophic lateral sclerosis(ALS).Methods 13 weeks old male transgenic ALS mice were selected and randomly divided into model group and Riluzole group.In addition,6 wild-type male...MORE Aim To explore the effects of Riluzole on motor function and muscle fibrosis in mice with amyotrophic lateral sclerosis(ALS).Methods 13 weeks old male transgenic ALS mice were selected and randomly divided into model group and Riluzole group.In addition,6 wild-type male mice were selected as the normal group.Motor abilit...