Apelin/APJ system is widely distributed in human tissues and exerts important biological effects through autocrine and paracrine signal pathways. It has important biological functions such as regulating vasomotor, positive muscle function, regulating vascular endothelial function, stimulating VSMC phenotype transformation and proliferation function, promoting angiogenesis, regulating fluid balance. Apelin/APJ system plays a key role in the development of atherosclerosis, hypertension, heart failure, myocardial infarction, atrial fibrillation and other cardiovascular diseases. In this paper, th...
