期刊论文

Study on Design,Synthesis and Application of Coumarin Derivatives

中文

南华大学学报(自然科学版)

1673-0062

2018

32

3

84-89

10.19431/j.cnki.1673-0062.2018.03.015

国家自然科学基金项目（11475079）；

本校为第一机构

香豆素及其衍生物具有很强荧光性.香豆素类荧光探针广泛应用于药物开发、疾病监测、金属离子检测等.随着工业化的发展,越来越多的有毒金属离子存在于我们生活环境之中,如何快速有效地识别金属离子显得尤为重要.用4-甲基-8-甲酰基-7-羟基香豆素、2-氨甲基吡啶反应合成了一种能够识别Cr^3＋的新型荧光分子探针MFHC.当溶液为乙腈时该配体对Cr^3＋具有高度的选择性识别作用,并且当其他离子在高于Cr^3＋浓度5倍的情况下该配体仍具有较强的抗干扰能力.荧光滴定实验表明：主体与配体之间的配位比应为1∶1,检测限为1.19×10^-11μmol/L.

Coumarin and its derivatives are highly fluorescent. Coumarin fluorescent probes are widely used in drug development,disease monitoring,and metal ion detection. With the development of industrialization,more and more toxic metal ions are present in our living environment.It is particularly important to identify metal ions efficiently and quickly.In this paper,a novel fluorescent molecular probe MFHC capable of recognizing Cr3＋was synthesized from 4-methyl-8-formyl-7-hydroxycoumarin and 2-aminomethylpyridine.When the solution is acetonitrile,th...