Based on Microscopic Optical Model of Skyrme force and Modified Skyrme Like Model,using the reaction of n+2~6pb reaction as example, we study the effect of Nuclear Matter Macroscopic Parameters on the nuclear reaction data.The results indicate that the nuclear reaction data is very sensitive to the value of symmetry energy at normal density Esyr,,(ρo) , the nucleon iso-scalar effective mass ms* and the incompressibility coefficient K0. Through the analysis of calculations, we can obtain the approximate values of those, i. e. Esy,,(po) ≈31.56 MeV,ms≈0. 67re(wh...