期刊论文

The Correlation Between Vitamin B12,Folic Acid and Megaloblastic Anemia in the Chinese Population： a Meta-analysis

中文

中南医学科学杂志

2095-1116

2015

2

125-131+149

10.15972/j.cnki.43-1509/r.2015.02.002

(2012AA063501):获国家863项目 (B2010-043):公共卫生与预防医学湖南省十二五重点学科、疾病控制评价中心南华大学校级重点实验室,湖南省卫生厅科研项目 (2014SCX10):湖南省研究生科研创新项目 (2011xwt05,2011xwt06):南华大学哲学社会科学基金

本校为第一机构

目的采用Meta分析方法综合定量评价中国人群维生素B12、叶酸与巨幼细胞性贫血相关性。方法检索国内外相关中英文数据库文献,并按照事先定义的纳入和排除标准,剔除不符合要求的文献,对纳入文献采用Meta分析方法进行综合定量分析,对17篇研究进行综合分析,累计病例625例,对照1 296例;用Stata 12.0进行分析,Q检验和I2检验反映异质性的大小,发表偏倚用漏斗图法、Begg秩相关和Egger线性回归法识别。结果巨幼细胞性贫血组的维生素B12含量低于对照组,差异有统计学意义（Z=5.86,P=0.00）;巨幼细胞性贫血组的叶酸含量低于对照组,差异有统计学意义（Z=5.58,P=0.00）。结论巨幼细胞性贫血与血清维生素B12、叶...

Objective To quantify the correlation between vitamin B12,folic acid and megaloblastic anemia in Chinese population. Methods Meta-analysis was performed by using Stata12. 0. Seventeen electronic databases of case-control studies from January 1959 to July 2014 were systematically searched on the basis of the published studies evaluating the correlation between vitamin B12,folic acid and megaloblastic anemia. A total of 625 cases and 1296 control cases were enrolled in the study. Cochrane＇s Q and I2 statistics were used to evaluate heterogeneity...