期刊论文

Effect of Cyclosporin A and Tacrolimus on Blood Glucose in Kidney Transplant Recipients with Type 1 Diabetes

中文

中南医学科学杂志

2095-1116

2014

42

1

70-73

10.15972/j.cnki.43-1509/r.2014.01.019

本校为第一机构

目的 观察和比较环孢素A与他克莫司对1型糖尿病肾移植受者血糖的影响,为1型糖尿病肾移植受者术后早期选择合理的免疫抑制剂提供参考.方法 收集1型糖尿病肾移植受者40例,随机分为CsA组和FK506组.同种异体肾移植术后,CsA组予环孢素A（CsA）＋吗替麦考酚脂（MMF）＋强的松（Pred）行免疫抑制治疗,共20例;FK506组予他克莫司（FK506）＋MMF＋Pred行免疫抑制治疗,共20例.各组受者术前均用胰岛素控制空腹血糖（FBG）和糖化血红蛋白（HbA1c）至基本正常,术后降糖方案与术前相同.观察和比较两组肾移植受者术前和术后第1、3、6个月的FBG浓度和HbA1c含量.结果 治疗的6个月内,CsA组有3例退出,FK506组有4例退...

Objective To observe the effect of cyclosporine A（CsA） and tacrolimus（FK506） on blood glucose in kidney transplant recipients with type 1 Diabetes,thereby for kidney transplant recipients with type 1 Diabetes,providing a reference for the rational selection ofimmunosuppressants in the early stage of renal post-transplantation. Methods A prospective study for 6 months was conducted in 40 kidney transplant recipients with type 1 Diabetes,who were randomly divided into CsA group （n=20） and FK506 group（n=20）.CsA group was treated with CsA b...