Seven novel morpholine compounds had been designed and synthetized, the structure of target compounds were confirmed by IR,NMR,ESI-MS and elemental analy-sis. All synthetized compounds were tested by forced swimming test and tail suspension test in mice. The result showed that these compounds display anti-depression activity of differ-ent degrees and the anti-depression effect of part of compounds with the same dose was sig-nificantly better than that of the blank group. The compounds containing a fluorinated sub-stituent at the 3-position of aromatic ring exhibited a high...