In this paper,3,5_difluoropropiophenone is synthetised using 3,5_difluorine ben_zene nitriles as the raw material reaction with ethyl magnesium bromide. Starting from 3,5_difluoropropiophenone,the four m_difluorine morpholinol hydrochloride are synthetised via several steps including bromination, amination, cyclization and acidification. Using the forced swim mice model of antidepressant pharmacology,the pharmacological effects of an_tidepressant of the synthesized compounds were observed. The target compound is synthe_tised and its structure i...