期刊论文

中文

南华大学学报(自然科学版)

1673-0062

2013

4

82-85

10.19431/j.cnki.1673-0062.2013.04.020

国家自然科学基金资助项目（11305086）； 博士启动基金资助项目（2011XQD55）；

本校为第一机构

邻菲罗啉衍生物的金属配合物对于DNA具有键合作用,有助于研发抗癌新药.以1,10-邻菲罗啉为原料合成了1,10-邻菲罗啉-5,6-二酮,然后与2-咪唑醛和醋酸铵在冰乙酸的环境下加热回流3.5 h,得到产品2,2’-联咪唑并[5,6-f]邻菲罗啉.将该产物与硝酸铜配位,制得铜配合物.用NMR、元素分析和IR对产物进行了表征.该目标产物有可能对DNA的切割起作用.

The metal complexes of phenanthroline ramification can bind to DNA through noncovalent interactions,which will help develop new anticancer drugs. 1,10-phenanthro- line-5,6-dione （DIONE） was synthesized by oxidation of 1,10-Phenanthroline. 2,2＇-bisg- lyoxaline[-5,6-f] phenanthroline （BGP） was then obtained by heating the mixture of DI- ONE / 2-imidazolecarboxaldehyde / ammonium acetate and glacial acetic acid to reflux. At last, copper complex of BGP was obtained by coordination reaction, which was BC, P charac- terized by IR, and all produ...