Natural polysaccharide with good biocompatibility and biodegradability is always used as drug delivery system which offered numerous advantages, including reducing sideeffects, prolonging duration time, retaining drug bioactivity, and thus improving the thera- peutic efficiency. This study aimed to propose a targeting human hepatocellular carcinoma cells (HepG2) drug delivery system based on pectin nanoparticles whose chains have a large number of galactose residues and evaluate their targeting effect on HepG2 cells. Cytotoxicity study(MTY)...