Objective To investigate the effects of arecoline on high fructose diet inducing insulin resistance in Wistar rats.Methods Insulin resistance(IR) animal model was established by feeding with high fructose diet.The IR model animals were randomly divided into four groups,including control(normal diet,Con),model(high fructose diet,HF),normal diet plus 5 mg/ml arecoline(Con+Are),and high fructose diet plus 5 mg/ml arecoline(HF+Are).Expression of GLUT-4 and p-PI3K in skeletal muscle was measured by western blot.Results Expression of GLUT...