期刊论文

中文

中南医学科学杂志

2095-1116

2011

39

5

507-510

10.15972/j.cnki.43-1509/r.2011.05.020

本校为第一机构

目的 探讨脂蛋白酯酶活化剂NO-1886对高糖/高脂/高胆固醇饲养的小型猪组织中CRP及IL-6蛋白表达的影响.方法 15只雄性巴马小型猪,按体重随机分为3组:正常组:喂基础猪饲料；三高组:喂高脂/高蔗糖/高胆固醇饲料(含10％猪油、37％蔗糖和2％胆固醇)；加药组:在高脂/高蔗糖/高胆固醇饲料里加1.0％NO-1886.5个月后处死动物,用油红O染色检测脂质在小型猪肝脏组织的蓄积情况,Western blot技术检测炎症因子CRP和IL-6在肝脏和脂肪等组织中的表达.结果 正常组和加药组肝脏结构正常,未见明显脂滴；而三高组肝脏组织内充满了大量大小不等的红染脂滴.与正常组比较,高脂/高糖/高胆固醇饮食能诱导巴马小型猪肝脏和...

Objective To investigate the role of lipoprotein lipase （LPL） activator NO-1886 on the protein expressions of C reactive protein（CRP） and IL-6 in high-fat/high-sucrose/high-cholesterol diet fed miniature pigs. Methods Male ,fifteen Bama-miniature pigs were randomized into three groups ： control group, high-fat/high-sucrose/high-cholesterol （control diet supplemented with 10% lard and 37% sucrose and 2% cholesterol. ） group and NO-1886 treated group. The pigs were sacrificed at the end of month 5. The degree of lipid deposition in liver t...