To investigate polyamidoamine (PAMAM) as a potential drug delivery carrier for camptotheein,complexes of the fourth and fifth generation PAMAM/Camptotheein were pre- pared in water by stirring method. The amounts of drug loading were determined by UV,and the release profile by I-IPLC in phosphate buffer solutions. The solubility of Camptothecin enhanced in PAMAM solutions and there were no obvious sustained release effects in PBS. PAMAM could not be used as carriers of ...