期刊论文

Establishment of New Zealand Rabbits Carotid Atherosclerosis Model Induced by Abnormal Shear Stress

中文

中南医学科学杂志

2095-1116

2011

39

3

258-261

10.15972/j.cnki.43-1509/r.2011.03.004

国家自然科学基金资助项目（30700325）； 湖南省教育厅重点项目（10A105）；

本校为第一机构

目的 建立异常剪切应力促兔颈总动脉粥样硬化(As)动物模型,论证不同程度As病变与不同程度和形式的剪切应力相关,为研究异常剪切应力在As中的作用奠定基础.方法 给予26只新西兰兔右颈总动脉硅胶管套环后等分为对照组(给予普通饮食)和高脂组(2%高胆固醇饮食);9周后处死动物,第0周和第9周收集血清测量总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC)、高密度脂蛋白胆固醇(HDLC)、甘油三酯(TG)水平;采集两侧颈总动脉,苏丹Ⅳ和HE染色观察颈总动脉As斑块面积.结果 高脂组血清TC、LDLC和HDLC水平明显较对照组高(P

Objective To build the rabbits model with carotid atherosclerosis produced by abnormal shear stress and demonstrate that different levels and forms of shear stress in the casts, upstream from the casts, and downstream from the casts in the carotid arteries can lead to different levels of carotid atherosclerosis. Methods Assembled with silastic collars around the right carotid arteries,all the New Zealand white rabbits were randomly divided into two groups, the control group （n = 13 ） and the high-cholesterol group （n = 13）. The rabbits in t...