期刊论文

The Trait of Immune Dysfunction of Old Age Sepsis Patients

中文

中南医学科学杂志

2095-1116

2010

38

1

109-111

10.3969/j.issn.2095-1116.2010.01.033

本校为第一机构

目的探讨老年脓毒症患者免疫失衡的特点。方法选取脓毒症患者118例,普通脓毒症组60例（34例老年患者和26例中青年对照人群）;重症脓毒症组58例（28例老年患者和30例中青年对照人群）。两组均应用酶联免疫吸附法（ELISA）检测TNF-α和IL-10,应用流式细胞仪技术检测外周血T、B淋巴细胞凋亡率,分别比较TNF-α水平、IL-10水平、IL-10/TNF-α和外周血T、B淋巴细胞凋亡率在老年患者和中青年对照人群之间的差异。结果在普通脓毒症组和（或）重症脓毒症组,老年患者血浆IL-10水平、IL-10/TNF-α比值、和外周血T、B淋巴细胞凋亡率显著高于中青年对照人群,而血浆TNF-α水平显著低于中青年对照人群。结论老年...

Objective To observe the trait of immune dysfunction of old age sepsis patients. Methods A total of 118 sepsis patients divided into two groups were studied,one group had 60 common sepsis patients contained 34 old age and 26 young people,and the other group had 58 severe sepsis patients contained 28 old age and 30 young people.To compare plasma concentrations of TNF–αand IL-10,and IL-10∕TNF–α,and T,B lymphocyte apoptosis rate between old aged and young people in each group. Results Plasma concentrations of IL-10,and IL-10∕TNF–α,and the ...