期刊论文

中文

南华大学学报(自然科学版)

1673-0062

2010

24

2

81-83+93

10.19431/j.cnki.1673-0062.2010.02.019

湖南省教育厅基金资助项目（08C762）；

本校为第一机构

1-氨基-2-羟基-6-硝基-茚可作药物和农药的中间体.以1-茚酮为原料,经过硝化反应、还原反应、脱水反应、环氧化反应、氨解反应得到1-氨基-2-羟基-6-硝基-茚,反应总收率为20.4%.通过偶极计算,我们确定了硝化产物主产物6-硝基-1-茚酮和副产物-4-硝基-1-茚酮,并通过柱层析对其分离;在环氧化反应中,使用m-CPBA作为环氧化试剂收率远高于其他过氧酸;目标产物后处理方法为,用重结晶代替柱层析.各中间体和目标化合物结构通过核磁共振、红外光谱以确定.

1 - Animo - 2 - Hydroxy - 6 - Nitroindane can be used for drug and pesticide intermediates. 1 - Animo - 2 - Hydroxy - 6 - Nitroindane was synthesized by nitration, reduction, dehydration, epoxidation and ammination of Inden - 1 - one with the yield of 20. 4%. The main product of nitration 6 - Nitroinden - 1 - one and byproducts 4 - Nitroinden -1 -one has been determined by dipole, and been separated by chromatography. The yield of epoxidation was improved by m - CPBA instead of using other peroxyacid. The post treatment method of the product was improved by recrystatlizing instead of the colum...