期刊论文

Synthesis and Anticancer Activities of 6 -Iodo -Chrysin Derivatives

中文

中南医学科学杂志

2095-1116

2010

38

2

200-202

10.3969/j.issn.2095-1116.2010.02.015

20809:教育部人文社会科学研究项目 07JJ6157:湖南省自然科学基金

本校为第一机构

目的 研究6-碘取代白杨素衍生物的体外抗癌活性.方法 合成6-碘取代的白杨素衍生物,并通过MTT法检测其对人急性粒细胞性白血病(HL-60)细胞、人结肠癌(HT-29)细胞和人胃癌(SGC-7901)细胞增殖的抑制作用.结果 合成了2个6-碘取代白杨素衍生物.结论 6-碘取代白杨素衍生物具有良好的抗癌活性(IC50=1.87～6.09 μmol/L).

Objective To study the antieancer activity of 6 -iodo -chrysin derivatives. Methods 6 -Iodo - ehrysin derivatives were prepared and their antieaneer activities in vitro were evaluated by the standard MTT method. Restilts Two 6 - iodo - chrysin derivatives were synthesized. Conclusion 6 - Iodo - chrysin derivatives possessed the potent anticaneer act...