期刊论文

中文

中南医学科学杂志

2095-1116

2010

38

6

743-745+749

10.3969/j.issn.2095-1116.2010.06.004

湖南省自然科学基金资助课题（06JJ50053）.；

本校为第一机构

目的探讨苯经呼吸道染毒致大鼠的生殖毒性作用。方法清洁级SD大鼠48只,雌、雄各半,随机分为4组：对照组、低（5 mg/m^3）、中（10 mg/m^3）、高（15mg/m^3）浓度苯染毒组;对照组动物吸入染毒柜内的空气,各染毒组动物吸入静式染毒柜内相应浓度的苯蒸气,每天2 h,连续染毒35天,染毒完成后第2天剖杀动物,分别检测雌、雄大鼠相关生殖毒性指标。结果中、高浓度苯可使雄鼠睾丸、附睾脏器系数降低,高浓度苯可使雌鼠卵巢脏器系数降低（P〈0.05）;各浓度苯致大鼠精子数量减少,分别为16.23、15.61、14.05（×10^7/附睾）,与对照组比较差异均有显著性（P〈0.05）,中、高浓度苯可使精子活动率降低,精子畸形率...

Objective To investigate the reproductive toxicity of benzene exposured by respiratory tract in rats. Methods 24 male and 24 female SD rats of clean grade were divided randomly and averagely into 4 groups respectively. The low,middle and high concentration benzene exposure group＇s rats were respectively breathed in 5 mg/m~3,10 mg/m~3 and 15 mg/m~3 benzene vapor at 1st to 35th day,2hr/day.Control group＇ s rats breathed in air of cabinet at 1st to 35th day,2hr/day.Animals were sacrificed at 36th day to detect the male and female rats＇ indicato...