Objective To establish different atherosclerotic animal models and compare the atherosclerotic lesion with human atherosclerotic plaque in pathological morphology. Methods The As models of minipig and New Zealand rabbit and ApoE -/- mouse were established with high lipid diet. The general morphology of As lesions was visual with Sudan IV staining, and micro - morphology of As lesions was analysed in paraffin slices with HE staining. Results The As lesions were the most obvious in aorta arch in three animal models. The abdominal aorta As lesion ...