期刊论文

Synthesis and Anticancer Activities of 7 -Alkoxy Chrysin Derivatives

中文

中南医学科学杂志

2095-1116

2009

37

5

516-517,531

湖南省自然科学基金（课题编号:07JJ6157）； 湖南省大学生研究性学习和创新性试验计划项目（课题编号:2008-269-132）资助；

本校为第一机构

目的 研究7-烷氧白杨素衍生物的体外抗癌活性. 方法 合成7-烷氧取代的白杨素衍生物,并通过MTT法检测其对人急性粒细胞性白血病(HL-60)细胞、人结肠癌(HT-29)细胞和人胃癌(SGC-7901)细胞增殖抑制作用. 结果 合成了6个烷氧取代白杨素衍生物,其中化合物2b对HT-29 细胞增殖的抑制作用强于5-Fu;化合物2a、2b、2e、2d对HL-60 细胞增殖的抑制作用强于5-Fu. 结论 7-烷氧白杨素衍生物具有潜在的抗癌活性.

Objective To study the anticancer activity of 7 - alkoxy chryain derivatives. Methods 7 - Alkoxy chrysin derivatives were prepared and their antlcancer activities in vitro were evaluated by the standard MTr method. Results Compound 2b showed more stronger activity against HT -29 cells than 5 - Fu, and compound 2a, 2b, 2e, 2d had stronger activity against HL - 60 cells than 5 - Fu. Conclusion 7 - Alkoxy chrysin der...