期刊论文

Research on Antimicrobial/Anticancer Activities of the Secondary Metabolite Bis(5-butyl-2-pyridinecarboxylato-N1,O2)-copper(II) from the Marine Fungus Fusarium sp.#ZZF51

中文

南华大学学报(自然科学版)

1673-0062

2008

22

3

1-4,20

10.19431/j.cnki.1673-0062.2008.03.001

863;2006AA09Z422:国家高技术研究发展计划（863计划） 20072058:国家自然科学基金 5-2007-XQD-002:南华大学博士启动基金

本校为第一机构

从南海红树林内源真菌Fusarium sp.#ZZF51的培养液中分离得到一金属铜络合物(1),通过波谱数据和单晶衍射数据解析其结构为:二(5-丁基-2-吡啶甲酸-N1,O2)合铜(Ⅱ),它是首次从自然界中被发现.体外活性实验初步表明:络合物(1)对四种细菌(金黄色葡萄球菌、枯草芽孢杆菌、大肠埃希氏菌和肠炎沙门氏菌)和三种癌细胞(KB、KBv200、HepG2)具有较强抑制活性,前者最低抑菌浓度(MIC值)分别为12.5、25、12.5和50 μg/mL,后者IC50值分别为3.54、3.68和25.12 μg/mL.

A metal complex(1)named bis(5-butyl-2-pyridinecarboxylato-N1,O2)-copper,the first time found in the nature,was isolated from the culture media of a mangrove endophytic fungus Fusarium sp.#ZZF51 from the South China Sea coast.Its structure was elucidated using spectroscopic methods and single crystal X-ray diffraction analysis.The antimicrobial cytotoxicity experiments exhibited complex(1)had mutagenicity activities against four aerobic reference strains Staphylococcus aureus,Bacillus subtilis,Escherichia coli,and Salmonella enteritidis with MIC...