期刊论文

The Effect of Zinc on Oxidative Stress in Hepatoma Carcinoma Cell

中文

中南医学科学杂志

2095-1116

2007

35

3

338-340

10.3969/j.issn.2095-1116.2007.03.010

本校为第一机构

目的探讨锌对人肝癌细胞氧化应激水平的影响。方法在体外培养的人肝癌细胞培养液中加入不同浓度的硫酸锌造成高锌环境或加入不同浓度的锌络合剂TPEN造成缺锌环境,测定人肝癌细胞超氧化物歧化酶活力（SOD）和丙二醛（MDA）的含量。结果肝癌细胞中SOD的活力随锌浓度的升高而逐渐增大、而MDA逐渐降低。结论锌能够增加人肝癌细胞SOD的活力,降低MDA的含量,提高抗氧化应激能力。

Objective To study the relation between zinc and level of oxidative stress in HepG2. Methods Activity of SOD and contents of MDA in HepG2 are detected by adding different density of zinc sulfate to culture solution of hepatoma carcinoma cell to result in surrounding of hypso - zinc, and by adding different density of zinc chelating agent TPEN to culture solution of hepatoma carcinoma cell to result in surrounding of nulli - zinc. Restilt The activity of SOD increase and contents of MDA degrade with increasing of zinc density in HepG2. Condusion Zinc can increase activity of SOD and decrease co...