期刊论文

中文

中南医学科学杂志

2095-1116

2007

35

1

71-73

10.3969/j.issn.2095-1116.2007.01.021

本校为其他机构

目的 观察罗哌卡因腹腔注射后对大鼠血液淋巴细胞DNA的影响,为不同浓度罗哌卡因的应用提供安全性依据.方法 Wistar大鼠72只,随机分为四组,对照组腹腔注射生理盐水,实验组(T1,T2,T3)按体重0.1 mL/100 g分别腹腔注射0.5%、0.75%、1.0%罗哌卡因.各组分别在腹腔注射后6、12和24小时3个时点各取6只动物,采用单细胞凝胶电泳检测血液淋巴细胞DNA损伤.结果 各实验组血淋巴细胞的彗星率和尾长均高于对照组,其中 T3组各时点与对照组相比差异有统计学意义(P＜0.05);T2组与对照组相比,在24小时时差异有显著性(P＜0.05).结论 低浓度(0.5%,0.75%)罗哌卡因腹腔注射24小时内对大鼠血液淋巴细胞无明显影响;高浓度...

Objective To explore the lymphocyte DNA damages after celiac injection ropivacaine in wistar rats and provide the experimental data for the security assessment of ropivacaine application. Methods Seventy - two male wistar rats were randomly and averagely divided into 4 groups. The groups were randomized to receive normal saline, 0.5%, 0.75% or 1.0% respectively by the celiac injection 0.1 mL every 100 g body weight. Six rats in every group in 6 h, 12 h and 24 h after the injection were killed, and every rat was phlebotomized blood approximately...