期刊论文

中文

中南医学科学杂志

2095-1116

2003

31

1

19-21,37

10.3969/j.issn.2095-1116.2003.01.006

日本大冡制药厂新药研究基金； 湖南省科技厅资助（NO:OOJZN 2032）.；

本校为第一机构

目的探讨合成化合物NO-1886是否降低高糖高脂饲料诱发的糖尿病新西兰兔的血清葡萄糖浓度和肝脏病变.方法体重2kg左右的雄性新西兰兔60只,随机选取20只饲以基础饲料为A组(正常对照组);20只饲以高糖高脂饲料为B组(糖尿病对照组);20只饲以高糖高脂饲料加1.0%NO-1886为C组(糖尿病治疗组).分别在0,4,8,12,16,20,24,28周时从禁食过夜的兔耳静脉抽取血样测定葡萄糖、甘油三酯水平.第32周末,处死动物,取肝脏一小块,10%***液固定,常规石蜡包埋切片,分别作H.E和肝糖原染色,光学显微镜下观察.结果糖尿病对照组1个月后即出现高血糖、高甘油三酯,并随着喂养时间延长而逐渐升高.正常对照组血糖、甘油三酯...

Objective To question whether NO - 1886 ,a synthetic compound, decreases serumal glucose or improves pathological changes in diabetic New Zealand White Rabbits induced by high sucrose and fat feed. Methods 60 rabbits about 2 kg weigh were randomly divided into 3 groups of normal control, diabetes, diabetes treatment, which were fed by basal diet, high sucros and fat feed or with 1.0% NO - 1886 respectively. The concentration of serumal glucose and triglyceride of rabbits, which were inhibited food over night, were analyzed in the 0,4, 8, 12, 16, 20, 24, 28th week respectively. These rabbits we...