期刊论文

A Study on Toxicity of the Gasoline Additive Methyl Tertiary Butyl Ether in Mice

中文

中南医学科学杂志

2095-1116

2002

30

3

221-223

10.3969/j.issn.2095-1116.2002.03.002

湖南省卫生厅科研项目基金资助 （课题编号 :995 1）；

本校为第一机构

目的通过研究汽油添加剂甲基叔丁基醚(MTBE)对小鼠体内谷胱甘肽(GSH)、谷胱甘肽过氧化物酶(GSH-Px)活性的改变以及骨髓微核、精子畸变率的影响,了解汽油添加剂甲基叔丁基醚的毒性.方法 40只健康昆明种成年小鼠,体重33.3±6.9 g,随机分为4组.灌胃染毒,染毒剂量分别为1 600、400、100和0 mg/kg.每天1次,每周5天,共计40天.结果 MTBE染毒各组小鼠体重轻度降低,染毒组全血及肝组织匀浆中GSH在低剂量染毒时增高,而高剂量时表现为降低,与对照组比较差异有显著性(P

Objective:To research toxicity of the gasoline additive methyl tertiary butyl ether(MTBE),the content of glutathione and activity of glutathione peroxidase were measured, and the rate of marrow micronucleus and semina deformity were observed in mice.Methods:40 mice were distributed into four groups averagely and were orally administrated at the dose of 1 600,400,100 and 0 mg/kg of MTBE,once daily, five days a week,for 40 days. Results:The content of GSH in whole blood and liver cytoplasm were reduced in 1 600 mg/kg dose group compared with that in the control group(P