期刊论文

Changes of Constitutive Nitric Oxide Synthase Gene Experssion in Rat′s Heart With Abdominial Aortic Coarctation induced Hypertension and Effect of L-Arginine

中文

中南医学科学杂志

2095-1116

1999

03

259-261

本校为第一机构

目的　观察腹主动脉缩窄性高血压大鼠早期心脏原生型一氧化氮合酶基因表达及 Ｌ精氨酸对血压的影响。方法　１４ ～１６ 周龄雄性 Ｗｉｓｔｅｒ 大鼠采用缩窄腹主动脉法制备高血压模型，口服 Ｌ精氨酸（ 精氨酸组） 和未服 Ｌ精氨酸（ 手术组） 的高血压大鼠及正常血压大鼠（ 对照组） 在同样条件下喂养２ 周后，测量血压，并采用逆转录多聚酶链反应技术检测一氧化氮合酶基因表达。结果　①大鼠腹主动脉缩窄后发生严重的高血压且心脏一氧化氮合酶基因表达增强；②口服 Ｌ精氨酸２ 周未能防止腹主动脉缩窄性高血压的发生。结论　腹主动脉缩窄性高血压大鼠早期心脏一氧化氮合酶基因表达增...

Objective to study the changes of nitric oxide synthase(NOS) gene expression in the early phase of abdominal aortic coarctation-induced hypertension rats′ heart and the effect of L-arginine supplementation on hypertension. Methods Male 14-16-week old Wister rats were made hypertensive models by abdominal aortic coarctation.L-arginine group was supplemented L-arginine,1.25g/liter,in their drinking water,Operated group and control group were not supplemented L-arginine in their drinking water.After two weeks,the right carotid artery was cannulat...