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Stromal Derived Factor-1 Is Up-Expressed in Atherosclerosis Lesion Induced by Low Density Lipoprotein Concentration Polarization

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成果类型:
期刊论文、会议论文
作者:
Wei, D. H.;Wang, G. X.*;Tang, C. J.;Qiu, J. H.;Zhao, J. B.;...
通讯作者:
Wang, G. X.
作者机构:
[Wang, G. X.; Wei, D. H.; Qiu, J. H.; Tang, C. J.; Deng, L. H.] Chongqing Univ, Key Lab Biorheol Sci & Technol, Minist Educ, Bioengn Coll, Shazhengjie 174, Chongqing 630044, Peoples R China.
[Wei, D. H.] Univ South China, Inst Cardiovascular Dis, Key Lab Arteriosclerol Hunan Provice, Hengyang, Peoples R China.
[Zhao, J. B.; Gregersen, H.] Aalborg Hosp Sci, Mech Sense, DK-9000 Aalborg, Denmark.
[Gregersen, H.; Deng, L. H.] Innovat Ctr, DK-9000 Aalborg, Denmark.
通讯机构:
[Wang, G. X.] C
Chongqing Univ, Key Lab Biorheol Sci & Technol, Minist Educ, Bioengn Coll, Shazhengjie 174, Chongqing 630044, Peoples R China.
语种:
英文
关键词:
Atherosclerosis;Concentration polarization;Low density lipoprotein;Low shear stress;Stromal derived factor-1
期刊:
IFMBE Proceedings
ISSN:
1680-0737
年:
2010
卷:
31
期:
1
页码:
402-405
会议名称:
6th World Congress of Biomechanics (WCB 2010)
会议论文集名称:
IFMBE Proceedings
会议时间:
AUG 01-06, 2010
会议地点:
Biomed Engn Soc Singapore, Singapore, SINGAPORE
会议主办单位:
Biomed Engn Soc Singapore
会议赞助商:
Global Enterprise Micromechan & Mol Med, Natl Univ Singapore (NUS), Li Ning, Singapore Tourism Board, Singapore Exhibit & Convent Bur, Profess Engn Publish
主编:
Lim, CT Goh, JCH
出版地:
233 SPRING STREET, NEW YORK, NY 10013, UNITED STATES
出版者:
SPRINGER
ISBN:
978-3-642-14514-8
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30970721]; Ministry of Education of ChinaMinistry of Education, China [104158]; National "111 plan" [B06023]
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
In this study, we designed a animal model to detect the effect of LDL concentration polarization on atherosclerosis and explore the molecular mechanism. A method to induce a defined local stenosis in straight segment of rabbit left carotid artery was developed. The rabbits were fed with normal or high fat/cholester food Numerical simulation and experimental measurement were used to analyze the feature of the blood flow and the LDL distribution. The arterial lesions were evaluated by using HE staining, collagen staining, Oil red O staining and H...

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